Faculty of Health & Medicine, University of Newcastle
Maree Gleeson is an Emeritus Professor in the Faculty of Health & Medicine at the University of Newcastle.
Maree has held leadership positions in health services, health policy and medical research. Maree had over 30 years of experience in the health sector in diagnostic immunology and 40 years in medical research.
Maree’s research involves the development of mucosal immunity in children and the role of respiratory infections in the predisposition to asthma, allergy and SIDS. A major focus for the past 25 years has been in the field of exercise immunology in collaboration with the Australian Institute of Sport on the causes and control of respiratory illness in elite athletes.
|Presentation Title :
Applications of Salivary IgA in clinical and research settings – identification of risk of infections
Salivary IgA is used as a marker of mucosal immunity and protection against infections. Saliva collection is easy, non-invasive and the physiology of salivary IgA well defined to allow interpretation of results. Measurement is usually by ELISA, but other automated technologies have been used.
In clinical settings, salivary IgA has been used for confirming IgA subclass deficiencies as saliva is predominantly IgA1. It has been used to indicate risk factors for mucosal infections, and adverse responses to blood transfusions.
In research settings, salivary IgA has been extensively used to identify athletes at risk of respiratory illness. Low levels of salivary IgA, IgA1 and excretions rates are associated with an increased risk of respiratory tract inflammation and infections. Salivary IgA is also responsive to psychological and other stressors.
Research in infants of SIDS and acute life threatening events (ALTE) of unknown cause, elevations of salivary IgA and IgM have been associated with unsuspected infections